Acryloyl-PCL-PEG-Alkyne, MW x 10K, n 3.4K is a heterobifunctional amphiphilic block copolymer composed of poly(ε-caprolactone) (PCL) and polyethylene glycol (PEG), with acryloyl and alkyne terminal groups. This grade combines approximately 10K PCL with 3.4K PEG, providing an especially strong PCL-rich architecture for hydrophobic assembly together with two distinct reactive groups for polymerization, crosslinking, click chemistry, and bioconjugation.
Key Features and Benefits
- Amphiphilic Block Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly, drug delivery, and biomaterial development.
- PCL MW 10K: Provides a biodegradable hydrophobic block for core formation, structural support, and incorporation of hydrophobic compounds.
- PEG MW 3.4K: Provides a hydrophilic segment specifically for aqueous compatibility and interfacial stabilization.
- PCL-Rich Architecture: The approximately 2.9:1 PCL-to-PEG molecular weight ratio favors hydrophobic interactions and core-forming assemblies while retaining a hydrophilic PEG component.
- Acryloyl Functionality: Provides a polymerizable terminal group for crosslinking, network formation, and incorporation into polymeric materials.
- Alkyne Functionality: Provides a reactive alkyne group for azide-alkyne click chemistry and conjugation with azide-containing molecules.
- Heterobifunctional Design: Provides orthogonal acryloyl and alkyne functionalities for sequential or selective polymer modification.
- Biodegradable Polymer Platform: Combines biodegradable PCL, hydrophilic PEG, and dual reactive end groups in one functional polymer platform.
Applications
- Nanoparticle Formulation: Supports preparation of functional polymeric nanoparticles and other nanoscale delivery systems.
- Drug Delivery: Supports polymeric carriers for hydrophobic compounds and controlled-delivery research.
- Click Chemistry: Supports Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules.
- Crosslinking and Polymerization: The acryloyl group supports polymerization and crosslinking for formation of functional polymer networks.
- Hydrogel Development: Supports incorporation into crosslinked hydrogel and polymer-network systems.
- Bioconjugation: Enables attachment of azide-functionalized peptides, proteins, targeting ligands, probes, and other molecules through alkyne chemistry.
- Biomaterial Research: Supports development of functional PEG-PCL materials, polymer networks, drug delivery systems, and advanced biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture, excessive heat, and prolonged light exposure. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
Acryloyl-PCL-PEG-Alkyne, MW x 10K, n 3.4K combines a strongly PCL-rich amphiphilic architecture with acryloyl and alkyne terminal functionalities. It specifically supports polymer self-assembly, nanoparticle formulation, drug delivery, click chemistry, crosslinking, hydrogel development, bioconjugation, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.