Acid-PEG4-mono-methyl ester
This product is a heterobifunctional PEG linker with a terminal carboxylic acid, a PEG4 spacer, and a protected methyl ester. The free acid couples efficiently with amines to form stable amide bonds, while the methyl ester provides a protected carboxyl for stepwise conjugation or later deprotection. The PEG4 chain enhances solubility and flexibility, making this an especially versatile intermediate for bioconjugation and synthesis.
Key Features and Benefits
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Carboxylic Acid Group: Couples readily with primary amines for amide bond formation.
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Methyl Ester: Protects the second carboxyl for controlled, stepwise chemistry.
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PEG4 Spacer: Adds solubility, flexibility, and reduced steric hindrance.
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Dual Reactivity: Supports orthogonal conjugation and sequential functionalization.
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High Purity: Produced to ≥95% purity for reproducibility.
Applications
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Bioconjugation: Links amines while retaining a protected acid for later modification.
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Peptide and Protein Chemistry: Integrates PEG units into biomolecules.
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Drug Delivery: Serves as a modular linker for PEGylated therapeutics.
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Organic Synthesis: Provides a protected PEG intermediate for stepwise derivatization.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Deprotect methyl ester under standard conditions when needed; use freshly prepared solutions.
This product combines carboxyl reactivity and a protected ester on a PEG4 backbone, specifically offering a flexible reagent for stepwise synthesis and conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
