8-Arm PLGA-NH2, MW 20K is a biodegradable multi-arm PLGA polymer with eight amine-functionalized arms and an approximate molecular weight of 20 kDa where its branched architecture specifically enables multivalent conjugation, crosslinking, drug delivery, and biomaterial applications.
Key Features and Benefits
- 8-Arm Architecture: Provides a branched polymer structure with multiple reactive arms.
- Amine Functionalization: Offers terminal primary amines for conjugation and derivatization.
- MW 20K: Moderate molecular weight supports efficient processing and versatile formulation development.
- Biodegradable: PLGA segments degrade into lactic acid and glycolic acid under physiological conditions.
- Multivalent Reactivity: Multiple amine groups specifically enable efficient conjugation, functionalization, and crosslinking.
Applications
- Bioconjugation: Enables coupling with NHS esters, activated carboxyl groups, and other amine-reactive molecules.
- Drug Delivery: Supports biodegradable controlled and sustained-release carrier systems.
- Crosslinking: Reacts with multifunctional electrophiles to form polymer networks.
- Hydrogels: Suitable for preparation of chemically crosslinked biodegradable hydrogel systems.
- Biomaterials: Used in scaffolds, coatings, nanoparticles, and tissue engineering research.
Storage and Handling
- Storage: Store at –20 °C in a sealed, dry container.
- Handling: Protect from moisture and excessive heat to minimize premature hydrolysis and polymer degradation.
8-Arm PLGA-NH2, MW 20K combines a branched eight-arm architecture with reactive amine functionality, specifically providing a versatile biodegradable platform for bioconjugation, crosslinking, drug delivery, and biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.