8-Arm PLGA-Mal, MW 10K is a biodegradable multi-arm PLGA polymer with eight maleimide-functionalized arms and an approximate molecular weight of 10 kDa where its branched architecture specifically enables thiol-selective conjugation, crosslinking, drug delivery, and biomaterial applications.
Key Features and Benefits
- 8-Arm Architecture: Provides a branched polymer structure with multiple reactive arms.
- Maleimide Functionalization: Enables selective conjugation with thiol-containing molecules.
- MW 10K: Low molecular weight supports efficient processing and flexible formulation development.
- Thiol Reactivity: Maleimide groups react efficiently with sulfhydryl groups to form stable thioether linkages.
- Multivalent Platform: Multiple maleimide groups enable efficient conjugation, crosslinking, and multifunctional modification.
Applications
- Bioconjugation: Enables coupling with thiol-containing peptides, proteins, ligands, and other biomolecules.
- Drug Delivery: Supports biodegradable drug delivery and controlled-release carrier systems.
- Crosslinking: Reacts with multifunctional thiols to form polymer networks.
- Hydrogels: Suitable for preparation of thiol-crosslinked biodegradable hydrogel systems.
- Biomaterials: Used in nanoparticles, scaffolds, coatings, and tissue engineering research.
Storage and Handling
- Storage: Store at –20 °C in a sealed, dry container, protected from moisture.
- Handling: Prepare solutions shortly before use and avoid prolonged exposure to aqueous or strongly basic conditions.
8-Arm PLGA-Mal, MW 10K combines biodegradable PLGA with multivalent maleimide functionality, providing an especially versatile platform for thiol-selective bioconjugation, crosslinking, drug delivery, and biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.