4-Arm PLGA-COOH, MW 20K is a four-arm poly(lactic-co-glycolic acid) polymer with terminal carboxyl groups. Its branched architecture provides multiple reactive sites specifically for conjugation, crosslinking, polymer functionalization, drug-delivery research, and biomaterial development.
Key Features and Benefits
- Four-Arm PLGA Architecture: Features four PLGA arms extending from a central core for branched polymer design.
- MW 20K: Provides an overall molecular weight especially suitable for polymer functionalization, network formation, and material development.
- Multiple Carboxyl Groups: Terminal –COOH groups provide reactive sites specifically for coupling with compatible amine-containing molecules.
- Amide Coupling Platform: Carboxyl groups support EDC/NHS and other suitable activation chemistries for amide bond formation.
- Biodegradable Copolymer: The PLGA arms contain hydrolyzable ester linkages that support gradual degradation under appropriate conditions.
- Lactide-Glycolide Backbone: Combines lactic acid- and glycolic acid-derived units within a biodegradable polyester platform.
- Multifunctional Polymer Platform: Four reactive chain ends support conjugation, crosslinking, network formation, and advanced polymer architectures.
Applications
- Polymer Functionalization: Supports modification of multiple terminal carboxyl groups with compatible amine-containing molecules.
- EDC/NHS Coupling: Enables activation of terminal carboxyl groups for subsequent reaction with primary amines.
- Amide Bond Formation: Supports covalent attachment of compatible amine-containing ligands, polymers, and biomolecules.
- Bioconjugation: Enables multivalent attachment of compatible peptides, proteins, and other amine-containing molecules.
- Crosslinking: Four-arm architecture supports development of crosslinked networks and functional polymer systems.
- Drug Delivery: Supports development of branched biodegradable polymer systems for drug-delivery and controlled-release research.
- Material Engineering: Enables development of branched, crosslinked, and chemically modified PLGA materials.
- Biomaterial Research: Supports development of functional biodegradable networks, particles, coatings, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
4-Arm PLGA-COOH, MW 20K combines a branched PLGA architecture with multiple terminal carboxyl groups and specifically supports multivalent conjugation, crosslinking, polymer functionalization, drug-delivery research, and biodegradable material development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.