4-Arm PLGA-Biotin, MW 5K is a four-arm poly(lactic-co-glycolic acid) polymer with terminal biotin groups. Its branched architecture provides multiple biotin sites specifically for affinity binding, multivalent assembly, nanoparticle functionalization, and biomaterial research.
Key Features and Benefits
- Four-Arm PLGA Architecture: Features four PLGA arms extending from a central core for branched polymer design.
- MW 5K: Provides a low molecular weight with good processability specifically for polymer functionalization, particle formulation, and material development.
- Multiple Biotin Groups: Terminal biotin groups provide multiple recognition sites specifically for avidin, streptavidin, and related biotin-binding proteins.
- High-Affinity Recognition: Biotin forms strong, specific noncovalent interactions with avidin and streptavidin.
- Multivalent Binding Platform: Multiple terminal biotin groups support affinity-based assembly, immobilization, and multivalent interactions.
- Biodegradable Copolymer: The PLGA arms contain hydrolyzable ester linkages that specifically support gradual degradation under appropriate conditions.
- Lactide-Glycolide Backbone: Combines lactic acid- and glycolic acid-derived units within a biodegradable polyester platform.
- Good Processability: The low molecular weight facilitates polymer dissolution, formulation, particle preparation, and functionalization.
Applications
- Avidin-Biotin Binding: Supports high-affinity interactions with avidin, streptavidin, and related biotin-binding proteins.
- Multivalent Assembly: Multiple biotin groups enable affinity-based assembly with compatible avidin- or streptavidin-containing components.
- Bioconjugation: Supports affinity-based association with biotin-binding proteins and other compatible functional systems.
- Nanoparticle Functionalization: Enables affinity-based modification and assembly of PLGA nanoparticles and related polymeric systems.
- Surface Modification: Supports immobilization of PLGA materials on compatible avidin- or streptavidin-functionalized surfaces.
- Affinity Capture: Enables development of multivalent biotin-mediated capture, immobilization, and recognition systems.
- Drug Delivery: Supports branched biodegradable polymer systems for drug-delivery and controlled-release research.
- Biomaterial Research: Supports development of biotin-functionalized polymers, particles, coatings, networks, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
4-Arm PLGA-Biotin, MW 5K combines a branched PLGA architecture with multiple terminal biotin groups, while its low molecular weight supports affinity assembly, nanoparticle functionalization, surface modification, and biodegradable material development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.