4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenol
This product is an aromatic tetrazine derivative featuring a phenolic hydroxyl group and a methyl-substituted tetrazine ring. The tetrazine moiety undergoes rapid inverse-electron-demand Diels–Alder (IEDDA) reactions with strained alkenes such as TCO or BCN, while the phenolic group provides a versatile handle for further functionalization, making this compound highly valuable in bioorthogonal chemistry and probe development.
Key Features and Benefits:
-
Tetrazine Moiety: Enables ultrafast IEDDA click chemistry with strained alkenes.
-
Phenolic Hydroxyl: Offers a reactive site for further derivatization or conjugation.
-
Methyl Substitution: Enhances stability and reactivity in click reactions.
-
High Purity: Ensures reproducibility in sensitive chemical biology workflows.
-
Compact Design: Useful as a building block in small-molecule probes and linkers.
Applications:
-
Bioorthogonal Chemistry: Enables rapid ligation with TCO/BCN for in vitro and in vivo labeling.
-
Probe Development: Serves as a precursor for fluorescent, radiolabeled, or affinity probes.
-
Bioconjugation: Supports site-specific protein, peptide, or antibody modification.
-
Synthetic Chemistry: Intermediate for advanced tetrazine-based conjugates.
Storage and Handling:
-
Storage: Store at –20 °C, protected from light and moisture.
-
Handling: Use anhydrous solvents (e.g., DMSO, DMF) and avoid prolonged light exposure to maintain tetrazine stability.
This product provides fast bioorthogonal reactivity and a versatile phenolic group, making it an especially excellent intermediate for conjugation, probe development, and advanced material applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
