3,4-Dibromo-Mal-PEG4-t-butyl ester
This product is a high-purity bifunctional PEG linker containing a 3,4-dibromomaleimide moiety for selective thiol labeling and a t-butyl ester for acid-cleavable protection of a terminal carboxylic acid. The PEG4 chain provides hydrophilicity, enhanced solubility, and optimal spacing for biomolecule modification. Specifically, this reagent is widely used for creating dual-functional conjugates, including drug-linker systems and targeted delivery vehicles.
Key Features and Benefits:
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Thiol-Reactive 3,4-Dibromomaleimide: Enables selective and efficient conjugation to cysteine residues or other thiol-containing molecules.
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t-Butyl Ester Protection: Provides a stable, acid-labile protecting group for the carboxylic acid, enabling orthogonal synthesis strategies.
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PEG4 Spacer: Improves aqueous solubility, flexibility, and reduces steric hindrance during conjugation.
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Heterobifunctional Design: Supports stepwise modification for advanced bioconjugate assembly.
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High Purity: Supplied at >95% purity for reproducible research and manufacturing results.
Applications:
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Protein and Peptide Conjugation: Attach thiol-reactive maleimide groups to biomolecules while retaining a protected acid for later functionalization.
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ADC and Drug-Linker Development: Build antibody-drug conjugates with precise spacer length and dual reactivity.
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Surface Modification: Functionalize nanoparticles or solid supports for bioassay and sensor applications.
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Multistep Organic Synthesis: Incorporate into orthogonal protection schemes for complex molecule assembly.
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Nanomedicine Research: Design targeted delivery systems with controlled release strategies.
Storage and Handling:
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Storage: Store at -20°C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to preserve maleimide and t-butyl ester stability.
3,4-Dibromo-Mal-PEG4-t-butyl ester offers precise control over thiol conjugation and carboxylic acid activation, making it a valuable tool for advanced bioconjugation, synthetic chemistry, and drug development workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
