3′-TBDMS-Bz-rA Phosphoramidite
This product is a benzoyl-protected adenosine phosphoramidite with a 3′-O-(tert-butyldimethylsilyl) (TBDMS) protecting group. This reagent is specifically used in RNA oligonucleotide synthesis, offering base protection, selective 2′-OH reactivity, and high stability during solid-phase synthesis.
Key Features and Benefits:
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Benzoyl Protection (Bz): Ensures selective protection of the adenine base.
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3′-TBDMS Group: Provides stable protection of the ribose 2′-OH position, removable under mild fluoride conditions.
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High Purity: Optimized for automated RNA synthesis.
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Improved Stability: Prevents undesired side reactions during chain elongation.
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Industry Standard: Fully compatible with commercial synthesizers.
Applications:
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RNA Oligonucleotide Synthesis: Incorporation of benzoyl-protected adenosine units.
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Therapeutics Development: Used in antisense oligonucleotides, siRNA, and mRNA synthesis.
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Research Tools: Ideal for probe design, diagnostics, and functional genomics.
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Structural Biology: Supports high-fidelity synthesis of modified RNA strands.
Storage and Handling:
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Storage: Store at –20 °C under inert atmosphere, protected from moisture and light.
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Handling: Use standard phosphoramidite protocols in anhydrous acetonitrile.
This product provides robust benzoyl and TBDMS protections, ensuring reliable performance in RNA oligonucleotide synthesis and therapeutic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
