3-Maleimidopropanoic Acid PFP Ester (CAS: 138194-55-5)
Product Overview
3-Maleimidopropanoic Acid PFP Ester is a thiol-reactive reagent that combines a maleimide group for selective conjugation with thiol groups and a pentafluorophenyl (PFP) ester for efficient coupling to amine groups. This reagent is widely used in bioconjugation and cross-linking applications, particularly for protein, peptide, and small molecule modification.
Features
- Maleimide Group: Reacts selectively with thiol groups to form stable thioether bonds.
- PFP Ester: Enables efficient coupling with primary amines.
- Versatile Reactivity: Suitable for modifying proteins, peptides, and small molecules.
- High Purity: ≥95% for consistent and reliable results.
- Biocompatibility: Ideal for use in sensitive biological systems.
Applications
- Bioconjugation: Dual modification of biomolecules via thiol and amine chemistries.
- Protein and Peptide Labeling: Site-specific functionalization for imaging or assay development.
- Cross-Linking: Stabilization of protein-protein or protein-small molecule interactions.
- Therapeutics: Development of antibody-drug conjugates (ADCs) and targeted delivery systems.
- Chemical Biology: Studies involving thiol and amine modifications in complex environments.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
