3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl chloride

3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl chloride

This product is a high-purity, reactive acyl chloride derivative of maleimide. The maleimide moiety reacts selectively with thiols to form stable thioether bonds, while the acyl chloride group allows rapid coupling with alcohols or amines to form esters or amides. This dual reactivity makes it especially valuable for synthesizing thiol-reactive linkers, crosslinkers, and bioconjugates in both research and industrial applications.

Key Features and Benefits

• Maleimide Group: Enables selective thiol coupling for stable thioether formation.

• Acyl Chloride Functionality: Rapidly couples with alcohols and amines.

• Bifunctional Reactivity: Supports orthogonal conjugation strategies.

• High Purity: Supplied at >95% purity for consistent results.

• Versatile Utility: Suitable for linker synthesis, crosslinkers, and surface modification.

Applications

• Synthesis of thiol-reactive linkers and crosslinkers.

• Protein and peptide conjugation via thiol chemistry.

• Preparation of bifunctional molecules for materials science.

• Surface and nanoparticle modification.

• Bioconjugation in drug delivery and diagnostics.

Storage and Handling

• Storage: Store at –20 °C under inert gas, dry, and protected from light.

• Handling: Use anhydrous solvents; avoid moisture to prevent hydrolysis of the acyl chloride.

This product combines maleimide thiol reactivity with acyl chloride chemistry, specifically enabling orthogonal functionalization for linker synthesis, crosslinking, and advanced bioconjugation.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.