(2-Pyridyldithio)-PEG4-Acid (CAS: 581065-93-2)
(2-Pyridyldithio)-PEG4-Acid acts as a heterobifunctional linker for bioconjugation and drug development. Its 2-pyridyldithiol group reacts with thiols to form disulfide bonds, while its terminal carboxylic acid couples with amine-containing molecules. The PEG4 spacer increases solubility and flexibility, reducing steric hindrance during conjugation.
Key Features:
- Functional Groups: 2-pyridyldithiol enables thiol reactivity, and the carboxylic acid facilitates amine coupling.
- PEG4 Spacer: Increases solubility and provides flexibility for efficient conjugation.
Applications:
- Bioconjugation: Links biomolecules through thiol-disulfide exchange and amide bond formation.
- Drug Development: Functions as a linker in synthesizing antibody-drug conjugates (ADCs) and targeted therapies.
Handling and Storage:
- Molecular Formula: C₁₆H₂₅NO₆S₂
- Molecular Weight: 391.50 g/mol
- Storage: Keep in a cool, dry place, away from light and moisture.
This compound is valuable in research and development for its ability to link molecules with precision, aided by its solubility and flexible spacer.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
