2,5-dioxopyrrolidin-1-yl 4-methyl-4-(pyridin-2-yldisulfaneyl)pentanoate linker contains an SPDP crosslinker and an NHS ester. The SPDP crosslinker is reactive toward amine and thiol groups and contains a cleavable disulfide bond. This crosslinker is also membrane permeable which allows for intracellular reactions to take place. The NHS ester can react with primary amines to form stable amide bonds. The hydrophilic PEG linker can increase the water solubility of the compound in aqueous media.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.