2-Bromo-2,2-dimethyl-acetamido-PEG3-acid (CAS: 2279944-67-9) is a polyethylene glycol (PEG)-based linker commonly used in the synthesis of PROTACs (proteolysis-targeting chimeras). It features a bromo group and a carboxylic acid, facilitating conjugation with various biomolecules.
Key Features:
- Functional Groups:
- Bromo Group: Enables alkylation with nucleophiles for covalent attachment.
- Carboxylic Acid: Forms amide bonds when reacting with primary amines.
- PEG3 Spacer:
- Increases water solubility, making the compound suitable for aqueous reactions.
- Reduces steric hindrance, improving molecular flexibility during conjugation.
Applications:
- PROTAC Synthesis:
- Links active molecules in the development of PROTACs for targeted protein degradation through the ubiquitin-proteasome pathway.
- Bioconjugation:
- Connects biomolecules such as peptides and proteins, supporting drug discovery and advanced research.
Handling and Storage:
- Molecular Formula: C₁₃H₂₄BrNO₆
- Molecular Weight: 370.24 g/mol
- Storage: Store at -20°C in a cool, dry place, away from light and moisture.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
