2-Boc-aminoethyl 2′-hydroxyethyl disulfide
This product is a cleavable heterobifunctional linker containing a Boc-protected amine, a hydroxyethyl group, and a disulfide bond. The Boc group specifically protects the amine for orthogonal deprotection and later conjugation. The disulfide enables reductive cleavage for controlled release, while the hydroxyl group provides a versatile handle for derivatization. This compact design makes the reagent especially valuable for bioconjugation and drug delivery.
Key Features and Benefits
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Boc-Protected Amine: Offers orthogonal reactivity after selective deprotection.
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Disulfide Bond: Enables reductive cleavage under intracellular conditions.
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Hydroxyl Group: Provides a modifiable site for further functionalization.
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Compact Structure: Reduces steric hindrance while maintaining reactivity.
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High Purity: Produced to ≥95% purity for consistent results.
Applications
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Drug Delivery: Builds cleavable linkers for controlled therapeutic release.
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Bioconjugation: Links molecules through reversible disulfide chemistry.
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Probe Development: Creates cleavable probes for imaging and diagnostics.
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Medicinal Chemistry: Serves as a modular building block in synthesis.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Deprotect Boc under mild acidic conditions; avoid prolonged exposure to reducing agents.
This product combines amine protection, hydroxyl derivatization, and cleavable disulfide chemistry, specifically offering a versatile tool for controlled conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
