2-(Azido-PEG2-amido)-1,3-propandiol
2-(Azido-PEG2-amido)-1,3-propandiol is a high-purity heterobifunctional PEG linker with a terminal azide for copper-catalyzed or strain-promoted click chemistry and a 1,3-propandiol moiety for further functionalization. The PEG2 spacer improves solubility, flexibility, and reduces steric hindrance, enabling efficient conjugation in both aqueous and organic systems. The amide linkage provides chemical stability, making this reagent suitable for bioorthogonal labeling, drug delivery, and materials science applications.
Key Features and Benefits
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Azide Group: Reacts via CuAAC or SPAAC with alkynes for bioorthogonal conjugation.
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1,3-Propandiol Moiety: Offers two hydroxyl groups for further derivatization.
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PEG2 Spacer: Enhances solubility, flexibility, and accessibility of reactive groups.
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Stable Amide Bond: Provides robustness under a variety of reaction conditions.
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High Purity: Supplied at >95% purity for reproducible and consistent results.
Applications
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Click Chemistry Conjugation: Couple to alkyne-bearing molecules or surfaces.
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Protein and Peptide Modification: Introduce azide groups for orthogonal labeling strategies.
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Nanoparticle and Surface Functionalization: Attach azide handles to hydroxyl-rich surfaces.
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Drug Delivery Systems: Incorporate azide reactivity into targeted delivery platforms.
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Diagnostic and Imaging Probes: Create multifunctional probes via orthogonal conjugation.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged moisture exposure to preserve azide reactivity.
This product combines azide click chemistry with hydroxyl-rich functionality in a hydrophilic PEG2 framework, offering versatility for orthogonal bioconjugation specifically in therapeutics, diagnostics, and materials science.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
