2-[(2,4-dinitrophenyl)disulfanyl]ethanol

2-[(2,4-Dinitrophenyl)disulfanyl]ethanol

2-[(2,4-Dinitrophenyl)disulfanyl]ethanol is a high-purity thiol-reactive reagent featuring a cleavable disulfide bond and a hydroxyl group. The 2,4-dinitrophenyl (DNP) moiety specifically activates the disulfide for rapid exchange with thiols, releasing a measurable DNP-thiol byproduct, while the terminal hydroxyl allows further functionalization. This reagent is especially ideal for synthesizing reducible linkers, crosslinkers, and redox-sensitive bioconjugates in drug delivery, diagnostics, and biomaterials research.

Key Features and Benefits

• Activated Disulfide: Facilitates rapid thiol–disulfide exchange under mild conditions.

• 2,4-Dinitrophenyl Group: Provides strong electron-withdrawing activation and enables spectrophotometric monitoring.

• Hydroxyl Group: Serves as a handle for further chemical derivatization.

• Cleavable Linkage: Disulfide bond enables controlled release under reducing conditions.

• High Purity: Supplied at >95% purity for reproducibility.

Applications of 2-[(2,4-Dinitrophenyl)disulfanyl]ethanol

• Preparation of reducible crosslinkers and cleavable linkers.

• Synthesis of redox-sensitive drug conjugates.

• Bioconjugation with reversible thiol modification.

• Functionalization of polymers and surfaces.

• Controlled release systems in therapeutics.

Storage and Handling

• Storage: Store at –20 °C, dry, and protected from light.

• Handling: Use anhydrous solvents; avoid prolonged exposure to reducing agents.

This product combines an activated disulfide for thiol exchange with a hydroxyl for further modification, enabling the creation of cleavable, redox-sensitive conjugates.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.