(2-pyridyldithio)-PEG1-PNP
This product is a heterobifunctional PEG linker containing a pyridyldisulfide group, a PEG1 spacer, and a para-nitrophenyl (PNP) ester. It enables reversible disulfide exchange and efficient amine conjugation, specifically offering dual functionality for bioconjugation.
Key Features and Benefits
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Pyridyldisulfide Group: Enables thiol-disulfide exchange and reversible conjugation.
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PNP Ester: Couples efficiently with primary amines to form stable amide bonds.
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PEG1 Spacer: Provides compact spacing and solubility.
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Dual Reactivity: Combines thiol exchange with amine conjugation.
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High Purity: Ensures reproducible results in conjugation workflows.
Applications
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Bioconjugation: Links thiol-containing molecules with amine-reactive biomolecules.
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Probe Development: Builds cleavable probes for diagnostics and imaging.
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Drug Delivery: Provides scaffolds for reducible linker design.
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Material Science: Functionalizes polymers and nanoparticles with reversible handles.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid reducing conditions before intended cleavage.
This product combines reversible thiol exchange with amine conjugation in a compact PEG1 scaffold, specifically providing a versatile linker for bioconjugation and material applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
