4-Arm-PEG-NH2 or 4-Arm-PEG-Amine is an amine-functionalized, multi-arm PEG polymer that easily cross-links into PEG hydrogels. It combines with carboxyl groups and reacts with active esters like NHS, TFP, and PFP. This makes it great for drug delivery, cell culture, and wound healing. Its excellent solubility and stability boost its use in medical devices and regenerative medicine.
4-Arm PEG Amine
4-Arm-PEG-NH2, or 4-Arm-PEG-Amine, is a multi-arm polyethylene glycol (PEG) molecule with four branches. Each arm ends with an amine (-NH2) group.
Key Features:
- Structure: It has a branched design, which is more compact than linear PEG. The four arms make it ideal for linking multiple molecules.
- Molecular Weight: Available in different weights like 2,000, 5,000, and 10,000. The molecular weight impacts its solubility and reactivity.
- Amine Groups: The amine ends react with carboxylic acids, aldehydes, and other molecules. This makes it useful for binding proteins, peptides, or drugs.
- Solubility: It dissolves easily in water and organic solvents, making it versatile.
- Applications:
- Drug Delivery: Often used to improve the solubility and stability of drugs.
- Bioconjugation: Attaches multiple biomolecules in a compact form.
- Hydrogels: Great for forming hydrogels in tissue engineering or wound healing.
- Surface Modification: Enhances biocompatibility on surfaces like nanoparticles or devices.
- Stability: PEG is resistant to degradation, which is why it’s trusted in many applications.
- Customizable: Molecular weight, arm length, and functionality can be tailored for specific needs.
In summary, 4-Arm-PEG-NH2 offers versatility in drug delivery, surface modification, and bioconjugation due to its reactive amine groups and compact design.