DBCO-PEG-triethoxysilane

DBCO-PEG-Triethoxysilane: Versatile Reagent for Surface Functionalization and Bioconjugation

Product Overview

DBCO-PEG-Triethoxysilane is a cutting-edge reagent designed for advanced surface functionalization and bioconjugation. This compound integrates a dibenzocyclooctyne (DBCO) group with a polyethylene glycol (PEG) spacer and a triethoxysilane group, offering a versatile tool for various scientific and industrial applications.

Key Features

• DBCO Group: Enables efficient, copper-free click chemistry for clean and precise coupling with azide-functionalized molecules.
• PEG Spacer: The polyethylene glycol (PEG) chain enhances solubility and reduces non-specific interactions, making it perfect for a wide range of bioconjugation tasks.
• Triethoxysilane Group: Provides strong attachment to surfaces like glass, silica, and metals, ensuring robust and stable modifications.

Applications

1. Surface Functionalization: Ideal for modifying surfaces of materials such as glass and silica, improving their reactivity and compatibility for various applications.
2. Bioconjugation: Facilitates the precise attachment of biomolecules to surfaces or substrates, making it suitable for use in biosensors, diagnostics, and other research applications.
3. Coatings and Adhesives: Useful in developing coatings and adhesives with enhanced surface properties and bioconjugation capabilities.

Benefits

• Efficient Coupling: The DBCO group allows for high-efficiency, copper-free coupling, minimizing side reactions and providing cleaner results.
• Improved Solubility: The PEG spacer reduces non-specific binding and enhances solubility, contributing to more accurate and reproducible outcomes.
• Strong Surface Attachment: The triethoxysilane group ensures durable and stable attachment to various surfaces, enhancing the functionality and longevity of modified materials.

Conclusion

DBCO-PEG-Triethoxysilane is an essential reagent for anyone involved in surface modification and bioconjugation. Its advanced features, including copper-free click chemistry, flexible PEG spacer, and robust surface attachment, make it a top choice for researchers and industrial professionals. Whether you’re working on surface coatings, biosensors, or other applications requiring precise modifications, DBCO-PEG-Triethoxysilane provides reliable and effective solutions.

Ref:

Wang, Y., 2021. Investigating the size effect of nanoparticles in Click Chemistry mediated cancer targeting (Doctoral dissertation, University of Illinois at Urbana-Champaign).

Ma, K. and Wiesner, U., 2017. Modular and orthogonal post-PEGylation surface modifications by insertion enabling penta-functional ultrasmall organic-silica hybrid nanoparticles. Chemistry of Materials, 29(16), pp.6840-6855.