Norbornene-PEG4-Propargyl
This high-purity heterobifunctional PEG linker has a norbornene group for rapid, catalyst-free inverse electron-demand Diels–Alder (IEDDA) cycloaddition with tetrazines and a terminal alkyne for copper-catalyzed azide–alkyne cycloaddition (CuAAC) click chemistry. The PEG4 spacer specifically enhances solubility, flexibility, and reduces steric hindrance, enabling efficient, orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
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Norbornene Group – Supports fast, catalyst-free tetrazine ligation under mild conditions.
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Propargyl Group – Enables CuAAC click chemistry for stable triazole formation with azides.
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PEG4 Spacer – Improves solubility, molecular flexibility, and accessibility of reactive groups.
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Orthogonal Reactivity – Allows sequential, site-specific conjugations without cross-reactivity.
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High Purity – Supplied at >95% purity for reproducible performance.
Applications
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Dual-functional linker for orthogonal conjugation strategies
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Protein, peptide, and nucleic acid labeling
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Multifunctional probe and diagnostic agent synthesis
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Antibody–drug conjugate (ADC) linker chemistry
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid prolonged exposure to moisture to maintain reactivity
This product combines tetrazine ligation via norbornene with alkyne click chemistry via propargyl, linked by a PEG4 spacer for solubility and flexibility, making it especially ideal for precise, orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
