Acid-PEG3-t-butyl ester
This product is a heterobifunctional PEG linker with a free carboxylic acid, a PEG3 spacer, and a protected t-butyl ester. The acid couples efficiently with primary amines to form stable amide bonds, while the t-butyl ester serves as a protected handle, easily deprotected under mild acidic conditions. The PEG3 chain adds solubility and flexibility, making this reagent an especially versatile intermediate for stepwise conjugation strategies.
Key Features and Benefits
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Carboxylic Acid Group: Couples with amines to generate stable amide bonds.
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t-Butyl Ester: Provides a protected carboxyl group for sequential modifications.
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PEG3 Spacer: Enhances solubility and reduces steric hindrance.
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Stepwise Chemistry: Allows controlled conjugation and linker extension.
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High Purity: Produced to ≥95% purity for reliable performance.
Applications
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Bioconjugation: Links biomolecules via acid/amine chemistry.
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Peptide Synthesis: Introduces PEG spacers with one protected acid site.
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Drug Delivery: Serves as a modular linker for PEGylated therapeutics.
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Organic Synthesis: Useful in multistep derivatization workflows.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Deprotect t-butyl ester under mild acidic conditions when needed.
This product combines a reactive carboxyl with a protected ester on a PEG3 backbone, specifically offering flexibility for stepwise PEGylation and bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
