Acid-PEG2-t-butyl ester
This product is a heterobifunctional PEG2 linker with a free terminal carboxylic acid and a t-butyl ester as an acid-labile protecting group. The PEG2 spacer provides hydrophilicity and compact flexibility, while the protected ester allows controlled deprotection for orthogonal conjugation strategies.
Key Features and Benefits:
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Carboxylic Acid Group: Couples efficiently with primary amines for stable amide bonds.
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t-Butyl Ester: Acid-labile protecting group for controlled release of functionality.
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PEG2 Spacer: Provides short hydrophilic spacing with reduced steric hindrance.
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High Purity: Ensures reproducibility in bioconjugation and synthetic workflows.
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Orthogonal Reactivity: Supports multifunctional, stepwise synthesis.
Applications:
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Bioconjugation: Enables amide coupling with biomolecules or polymers.
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Drug Delivery: PEGylated linker enhances solubility and controlled release.
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Surface Functionalization: Functionalizes nanoparticles, hydrogels, or polymer scaffolds.
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Synthetic Chemistry: Useful as a protected intermediate in PEG-based conjugates.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve ester and acid stability.
This product combines a free acid with an orthogonally protected ester in a short PEG framework, making it an especially versatile tool for controlled conjugation and advanced material applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
