Acid-PEG7-t-butyl ester
This product is a heterobifunctional PEG linker featuring a terminal carboxylic acid and a t-butyl ester as an acid-labile protecting group. The PEG7 spacer enhances solubility, flexibility, and spacing, making it especially useful for orthogonal conjugation, drug delivery, and probe development.
Key Features and Benefits:
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Carboxylic Acid: Enables efficient amide coupling with primary amines.
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t-Butyl Ester: Provides acid-labile protection for controlled deprotection.
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PEG7 Spacer: Improves solubility, hydrophilicity, and steric accessibility.
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Orthogonal Design: Supports multi-step synthesis strategies.
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High Purity: Ensures reproducibility in bioconjugation workflows.
Applications:
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Bioconjugation: Couples biomolecules with precise, controlled linker chemistry.
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Drug Delivery: PEGylated design enhances solubility and circulation properties.
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Probe Development: Builds multifunctional scaffolds for imaging or diagnostics.
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Synthetic Chemistry: Serves as an intermediate for orthogonal conjugation.
Storage and Handling:
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Storage: Store at –20 °C in a moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMSO, DMF) to maintain acid and ester stability.
This product offers a dual-functional design with acid-labile ester protection and PEG7 spacing, making it an especially versatile tool for bioconjugation and therapeutic development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
