HBr·H2N-O-(CH2)5-COOH
This product is an aminooxy-functionalized carboxylic acid provided as the hydrobromide salt. The aminooxy group enables chemoselective oxime ligation with aldehydes and ketones, while the terminal carboxyl group allows further conjugation through amide coupling. Its (CH2)5 spacer offers flexibility and accessibility, making it an especially useful bifunctional linker for bioconjugation and synthesis.
Key Features and Benefits
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Aminooxy Group: Forms stable oxime bonds with aldehydes and ketones.
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Carboxylic Acid Group: Couples readily with amines to form amide linkages.
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(CH2)5 Spacer: Provides flexibility and spacing between reactive groups.
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Hydrobromide Salt: Improves stability and handling.
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High Purity: Produced to ≥95% purity for reproducible results.
Applications
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Bioconjugation: Links aldehyde/ketone-containing biomolecules with amine-functionalized partners.
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Probe Development: Builds oxime-linked probes for imaging and diagnostics.
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Drug Delivery: Serves as a bifunctional linker in PEGylation or conjugate design.
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Organic Synthesis: Acts as a versatile intermediate for multifunctional molecules.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use freshly prepared solutions; avoid repeated freeze–thaw cycles.
This product integrates aminooxy and carboxyl groups in a flexible chain, specifically providing a versatile tool for oxime ligation, amide coupling, and multifunctional conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
