Biotin-PEG12-NH-Mal
Biotin-PEG12-NH-Mal is a high-purity heterobifunctional PEG linker combining a biotin group for high-affinity binding to streptavidin/avidin systems and a maleimide group for selective conjugation with thiol groups. The PEG12 spacer specifically enhances hydrophilicity, flexibility, and accessibility, minimizing steric hindrance in bioconjugation workflows.
Key Features
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Biotin moiety for strong, specific binding to streptavidin or avidin
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Maleimide group for rapid, selective thiol coupling
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PEG12 spacer improves solubility and reduces aggregation
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High reactivity and stability in aqueous and mild conditions
Applications
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Site-specific labeling of proteins, peptides, and antibodies
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Streptavidin-based capture and detection systems
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Targeted delivery systems and affinity purification
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Biosensor and diagnostic assay development
Storage and Handling
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Store at –20 °C, protected from light and moisture
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Warm to room temperature before use
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Avoid repeated freeze-thaw cycles
The product features a biotin group for avidin/streptavidin binding and a maleimide group for thiol-specific conjugation, specifically connected by a hydrophilic PEG12 spacer for enhanced solubility and reduced steric hindrance.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
