Biotin-LC-LC-NHS Ester
This product is a biotinylation reagent featuring a biotin group, an NHS ester for amine coupling, and a long-chain LC–LC spacer specifically for reduced steric hindrance. The extended PEG-like spacing specifically improves solubility and accessibility, making it ideal for protein labeling, probe development, and bioconjugation.
Key Features and Benefits:
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Biotin Moiety: Provides strong avidin/streptavidin binding.
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NHS Ester: Efficiently couples with primary amines under mild conditions.
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LC–LC Spacer: Reduces steric hindrance and enhances solubility.
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Long Reach: Improves biotin accessibility in complex biomolecular systems.
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High Purity: Ensures reproducibility in labeling workflows.
Applications:
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Protein Labeling: Biotinylates antibodies, enzymes, and other amine-containing biomolecules.
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Probe Development: Builds biotinylated probes for diagnostics and imaging.
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Bioconjugation: Couples biotin to peptides, polymers, and nanoparticles.
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Drug Delivery: Provides long, flexible spacers for improved biotin-targeted systems.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use freshly prepared solutions; NHS ester is moisture-sensitive.
This product combines biotin binding with amine-reactive NHS chemistry and long-chain flexibility, making it especially effective for reducing steric hindrance in labeling.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
