Amino-PEG12-t-butyl ester
This product is a heterobifunctional PEG linker containing a terminal amine, a PEG12 spacer, and a tert-butyl ester. It specifically enables amide coupling and staged deprotection, providing solubility, extended spacing, and controlled reactivity for bioconjugation and synthesis.
Key Features and Benefits
-
Primary Amine: Couples efficiently with carboxyls, NHS esters, or activated linkers.
-
t-Butyl Ester: Protects the carboxyl group for controlled deprotection.
-
PEG12 Spacer: Provides long-chain flexibility, solubility, and biocompatibility.
-
Dual Reactivity: Combines amine coupling with protected acid functionality.
-
High Purity: Ensures reproducibility in sensitive conjugation workflows.
Applications
-
Bioconjugation: Links PEG scaffolds to biomolecules with orthogonal reactivity.
-
Probe Development: Builds multifunctional probes with staged conjugation control.
-
Drug Delivery: Provides PEG scaffolds with solubility and protected reactive groups.
-
Organic Synthesis: Serves as a versatile intermediate for linker design.
Storage and Handling
-
Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
-
Handling: Use anhydrous solvents such as DMF or DMSO; avoid premature hydrolysis or deprotection.
This product integrates amine chemistry with a protected acid in a PEG12 scaffold, specifically offering solubility, flexibility, and staged reactivity.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
