HO-PEG3-t-butyl ester
This product is a high-purity PEG derivative with a terminal hydroxyl group and a tert-butyl ester at opposite ends, specifically connected by a PEG3 spacer for solubility and flexibility.
Key Features and Benefits
- Hydroxyl Group – Enables further derivatization through esterification, etherification, or coupling chemistries.
- t-Butyl Ester – Acid-labile protecting group that can be selectively removed to yield the free carboxylic acid.
- PEG3 Spacer – Improves solubility, reduces steric hindrance, and provides conformational flexibility.
- High Purity – Suitable for organic synthesis, bioconjugation, and material science applications.
Applications
- Intermediate for functional PEG derivatives
- Building block in drug conjugates and prodrugs
- Surface and material modification
- Custom linker design for bioconjugation workflows
Storage & Handling
- Storage: Store at –20 °C, dry, and protected from light.
- Use: Dissolve in anhydrous solvents (e.g., DCM, DMF). Avoid moisture and repeated freeze–thaw cycles.
This product provides a hydroxyl group for functionalization and a t-butyl ester for protected carboxyl chemistry, connected by a PEG3 spacer that specifically enhances solubility and flexibility in conjugation and synthesis.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
