Cbz-N-Amido-PEG36-acid
This product is a long-chain PEG36 linker with a Cbz-protected amide and a terminal carboxylic acid. The extended PEG36 spacer provides excellent hydrophilicity, flexibility, and spacing, while the Cbz group offers stable carbamate protection for orthogonal conjugation strategies.
Key Features and Benefits:
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Cbz-Protected Amide: Stable carbamate protection, removable under hydrogenolysis.
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Carboxylic Acid Group: Couples with primary amines to form stable amide bonds.
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PEG36 Spacer: Provides maximum solubility, flexibility, and reduced steric hindrance.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
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Orthogonal Design: Supports stepwise, controlled, and multifunctional synthesis.
Applications:
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Bioconjugation: Enables precise attachment of proteins, peptides, and biomolecules with long PEG spacing.
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Drug Delivery: PEGylated linker improves solubility, stability, and pharmacokinetics.
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Surface Modification: Functionalizes nanoparticles, hydrogels, and polymers.
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Material Science: Incorporates into PEGylated scaffolds for advanced material systems.
Storage and Handling:
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Storage: Store at –20 °C in a dry, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve Cbz and acid integrity.
This product provides long-chain PEG spacing with dual functionality, making it an especially versatile reagent for advanced synthesis, drug delivery, and surface engineering.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
