PLLA-PEG-Folate (PLLA-PEG-FA), MW x 20K, n 5K provides a biodegradable, folate-functionalized amphiphilic block copolymer for targeted drug delivery, nanoparticle formulation, and biomaterials research and specifically combines a 20 kDa poly(L-lactic acid) (PLLA) segment with a 5 kDa hydrophilic polyethylene glycol (PEG) chain terminated with folic acid (FA). This PLLA-rich structure specifically supports hydrophobic drug encapsulation and folate receptor-mediated targeting in compatible experimental systems.
Key Features and Benefits
- 20 kDa PLLA Block: Provides a biodegradable hydrophobic polyester segment specifically for nanoparticle formation, drug encapsulation, and controlled-release research.
- 5 kDa PEG Block: Introduces a hydrophilic polymer chain that specifically supports surface hydration, aqueous dispersion, and colloidal stabilization.
- Folate Functionalization: Incorporates a folic acid targeting moiety for investigating interactions with folate receptor-expressing cells.
- Folate Receptor Targeting: Supports studies of receptor-mediated binding and cellular uptake in suitable folate receptor-positive models.
- Amphiphilic Block Copolymer: Combines hydrophobic PLLA and hydrophilic PEG segments specifically for self-assembly into polymeric nanoparticles and related nanostructures.
- Biodegradable Polyester Backbone: Contains hydrolytically degradable ester bonds for evaluating polymer degradation and drug release behavior.
- PLLA-Rich Composition: Features a 4:1 nominal PLLA-to-PEG molecular weight ratio for investigating hydrophobic core formation and drug-loading behavior.
- Hydrophilic Surface Modification: Provides PEG chains that may reduce nonspecific interactions and improve colloidal stability under suitable formulation conditions.
- Functionalized Nanocarrier Design: Combines biodegradable polymer architecture with folate targeting functionality for advanced drug delivery research.
Applications
- Folate-Targeted Drug Delivery: Supports development of polymeric carriers designed to interact with folate receptor-expressing cells.
- Polymeric Nanoparticle Development: Enables preparation of biodegradable nanoparticles containing hydrophobic PLLA domains and hydrophilic PEG surfaces.
- Cancer Drug Delivery Research: Supports investigation of folate receptor-targeted nanocarriers in compatible cancer cell models.
- Hydrophobic Drug Encapsulation: Enables formulation studies involving incorporation of hydrophobic research compounds into PLLA-containing polymeric carriers.
- Controlled Drug Release: Supports evaluation of drug release kinetics associated with polyester degradation and polymer composition.
- Folate Receptor-Mediated Uptake: Enables investigation of receptor-associated cellular binding and internalization of folate-functionalized nanoparticles.
- Polymeric Micelle Research: Supports studies of amphiphilic self-assembly, particle formation, and formulation stability.
- Biomaterials Research: Enables development of biodegradable, folate-functionalized polymer systems specifically for studying cellular interactions.
- Polymer Characterization: Supports analysis of block composition, nanoparticle size, drug-loading efficiency, degradation behavior, and targeting performance.
Storage and Handling
- Storage: Store at −20°C in a dry, tightly sealed container, preferably under an inert atmosphere, unless otherwise specified. Protect from moisture, excessive heat, and prolonged light exposure to preserve polymer integrity and folate functionality.
- Handling: Handle under dry conditions and dissolve in a compatible solvent, such as DMSO or DMF, after confirming product-specific solubility. Select an appropriate nanoprecipitation, solvent exchange, or emulsification method based on polymer composition and formulation requirements.
- For targeted nanoparticle research, optimize polymer concentration, solvent composition, particle preparation conditions, and folate presentation. Evaluate folate receptor-mediated uptake using appropriate receptor-positive and receptor-negative controls. Minimize prolonged exposure to strongly acidic or alkaline conditions that may accelerate polyester degradation.
PLLA-PEG-Folate (PLLA-PEG-FA), MW x 20K, n 5K combines a biodegradable PLLA segment with a hydrophilic PEG chain and folate targeting functionality and specifically supports folate receptor-targeted nanoparticle development, hydrophobic drug encapsulation, controlled-release studies, cancer drug delivery research, and advanced biomaterials applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.