PLLA-PEG-Folate (PLLA-PEG-FA), MW x 20K, n 2K provides a biodegradable, folate-functionalized amphiphilic block copolymer for targeted drug delivery, nanoparticle formulation, and biomaterials research and specifically combines a 20 kDa poly(L-lactic acid) (PLLA) segment with a 2 kDa hydrophilic polyethylene glycol (PEG) chain terminated with folic acid (FA). This PLLA-rich structure specifically supports hydrophobic drug encapsulation, controlled-release research, and folate receptor-mediated targeting in compatible experimental systems.
Key Features and Benefits
- 20 kDa PLLA Block: Provides a biodegradable hydrophobic polyester segment specifically for nanoparticle formation, drug encapsulation, and controlled-release research.
- 2 kDa PEG Block: Introduces a hydrophilic polymer chain that supports surface hydration, aqueous dispersion, and colloidal stabilization.
- Folate Functionalization: Incorporates a folic acid targeting moiety for investigating interactions with folate receptor-expressing cells.
- Folate Receptor Targeting: Supports studies of receptor-mediated binding and cellular uptake in suitable folate receptor-positive models.
- Amphiphilic Block Copolymer: Combines hydrophobic PLLA and hydrophilic PEG segments specifically for self-assembly into polymeric nanoparticles and related nanostructures.
- Biodegradable Polyester Backbone: Contains hydrolytically degradable ester bonds specifically for evaluating polymer degradation and drug release behavior.
- PLLA-Rich Composition: Features a 10:1 nominal PLLA-to-PEG molecular weight ratio for investigating hydrophobic core formation and drug-loading behavior.
- Hydrophilic Surface Modification: Provides PEG chains that may reduce nonspecific interactions and improve colloidal stability under suitable formulation conditions.
- Functionalized Nanocarrier Design: Combines biodegradable polymer architecture with folate targeting functionality for advanced drug delivery research.
Applications
- Folate-Targeted Drug Delivery: Supports development of polymeric carriers designed to interact with folate receptor-expressing cells.
- Polymeric Nanoparticle Development: Enables preparation of biodegradable nanoparticles containing hydrophobic PLLA domains and hydrophilic PEG surfaces.
- Cancer Drug Delivery Research: Supports investigation of folate receptor-targeted nanocarriers in compatible cancer cell models.
- Hydrophobic Drug Encapsulation: Enables formulation studies specifically involving incorporation of hydrophobic research compounds into PLLA-containing polymeric carriers.
- Controlled Drug Release: Supports evaluation of drug release kinetics specifically associated with polyester degradation and polymer composition.
- Folate Receptor-Mediated Uptake: Enables investigation of receptor-associated cellular binding and internalization of folate-functionalized nanoparticles.
- Polymeric Micelle Research: Supports studies of amphiphilic self-assembly, particle formation, and formulation stability.
- Biomaterials Research: Enables development of biodegradable, folate-functionalized polymer systems for studying cellular interactions.
- Polymer Characterization: Supports analysis of block composition, nanoparticle size, drug-loading efficiency, degradation behavior, and targeting performance.
Storage and Handling
- Storage: Store at −20°C in a dry, tightly sealed container, preferably under an inert atmosphere, unless otherwise specified. Protect from moisture, excessive heat, and prolonged light exposure to preserve polymer integrity and folate functionality.
- Handling: Handle under dry conditions and dissolve in a compatible solvent, such as DMSO or DMF, after confirming product-specific solubility. Select an appropriate nanoprecipitation, solvent exchange, or emulsification method based on polymer composition and formulation requirements.
For targeted nanoparticle research, optimize polymer concentration, solvent composition, particle preparation conditions, and folate presentation. Evaluate folate receptor-mediated uptake using appropriate receptor-positive and receptor-negative controls. Minimize prolonged exposure to strongly acidic or alkaline conditions that may accelerate polyester degradation.
PLLA-PEG-Folate (PLLA-PEG-FA), MW x 20K, n 2K combines a biodegradable PLLA segment with a hydrophilic PEG chain and folate targeting functionality and specifically supports folate receptor-targeted nanoparticle development, hydrophobic drug encapsulation, controlled-release studies, cancer drug delivery research, and advanced biomaterials applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.