PLLA-PEG-COOH, MW x 3K, n 5K provides a biodegradable, carboxyl-functionalized block copolymer for drug delivery, nanoparticle formulation, and biomaterials research and specifically combines poly(L-lactic acid) (PLLA, 3 kDa) with polyethylene glycol (PEG, 5 kDa) and a terminal carboxyl group. This PEG-rich amphiphilic polymer specifically supports nanoparticle assembly, surface functionalization, and biomolecular conjugation.
Key Features and Benefits
- Biodegradable Block Copolymer: Combines biodegradable PLLA with hydrophilic PEG to specifically support drug delivery and biomaterial applications.
- Defined Molecular Weight: Features a 3 kDa PLLA block and a 5 kDa PEG block specifically for polymer formulation and characterization studies.
- Terminal Carboxyl Functionality: Provides a reactive COOH group for covalent attachment of amine-containing molecules.
- Amphiphilic Structure: Combines hydrophobic PLLA and hydrophilic PEG segments to specifically support polymer self-assembly and nanoparticle formation.
- EDC/NHS Coupling Compatibility: Enables carboxyl activation and subsequent conjugation with primary amines through stable amide bond formation.
- PEG-Rich Composition: The 3K/5K block ratio provides a relatively high hydrophilic fraction for investigating nanoparticle hydration, colloidal stability, and assembly behavior.
- PEG Surface Modification: The 5 kDa PEG segment supports particle surface hydration and investigation of nonspecific protein adsorption.
- Biodegradable PLLA Segment: Supports investigation of hydrolytic degradation and polymer-based controlled release systems.
- Versatile Functionalization: Enables conjugation of peptides, proteins, targeting ligands, and other amine-functionalized molecules.
Applications
- Drug Delivery Research: Supports development of biodegradable polymeric carriers for drug encapsulation and controlled release studies.
- Nanoparticle Formulation: Useful for preparing polymeric nanoparticles and evaluating particle size, stability, and surface characteristics.
- Polymeric Micelle Research: Supports investigation of amphiphilic polymer self-assembly and hydrophobic compound encapsulation.
- Targeted Drug Delivery: Enables attachment of amine-containing targeting ligands to polymeric delivery systems.
- Bioconjugation Research: Useful for EDC/NHS-mediated coupling of peptides, proteins, and other amine-functionalized biomolecules.
- Surface Functionalization: Supports modification of polymer nanoparticles with functional molecules and biological ligands.
- Biomaterials Research: Useful for developing biodegradable polymer systems for tissue engineering and biomedical material studies.
- Controlled Release Studies: Supports investigation of PLLA degradation, polymer composition, and drug release behavior.
- Polymer Characterization: Enables studies of molecular weight, hydrophilic-hydrophobic balance, self-assembly, and physicochemical properties.
Storage and Handling
- Storage: Store at −20°C in a dry, tightly sealed container unless otherwise specified. Protect from moisture and excessive heat.
- Handling: Handle under dry conditions to minimize moisture exposure. For carboxyl conjugation, use suitable EDC/NHS activation conditions and freshly prepared reaction solutions when appropriate.
PLLA-PEG-COOH, MW x 3K, n 5K combines biodegradable PLLA with a relatively long hydrophilic PEG segment and reactive terminal carboxyl functionality, while its PEG-rich composition supports nanoparticle development, targeted drug delivery, bioconjugation, controlled release, and advanced biomaterials research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.