PLLA-PEG-COOH, MW x 3K, n 3K provides a biodegradable, carboxyl-functionalized block copolymer for drug delivery, nanoparticle formulation, and biomaterials research specifically combines poly(L-lactic acid) (PLLA, 3 kDa) with polyethylene glycol (PEG, 3 kDa) and a terminal carboxyl group. This amphiphilic polymer specifically supports nanoparticle assembly, surface functionalization, and biomolecular conjugation.
Key Features and Benefits
- Biodegradable Block Copolymer: Combines biodegradable PLLA with hydrophilic PEG to support drug delivery and biomaterial applications.
- Defined Molecular Weight: Features a 3 kDa PLLA block and a 3 kDa PEG block for polymer formulation and characterization studies.
- Terminal Carboxyl Functionality: Provides a reactive COOH group for covalent attachment of amine-containing molecules.
- Amphiphilic Structure: Combines hydrophobic PLLA and hydrophilic PEG segments to specifically support polymer self-assembly and nanoparticle formation.
- EDC/NHS Coupling Compatibility: Enables carboxyl activation and subsequent conjugation with primary amines through stable amide bond formation.
- Balanced Block Molecular Weights: The 3K/3K composition provides equal nominal block molecular weights for investigating hydrophilic-hydrophobic balance and assembly behavior.
- PEG Surface Modification: The 3 kDa PEG segment supports particle surface hydration and investigation of nonspecific protein adsorption.
- Biodegradable PLLA Segment: Supports investigation of hydrolytic degradation and polymer-based controlled release systems.
- Versatile Functionalization: Enables conjugation of peptides, proteins, targeting ligands, and other amine-functionalized molecules.
Applications
- Drug Delivery Research: Supports development of biodegradable polymeric carriers for drug encapsulation and controlled release studies.
- Nanoparticle Formulation: Useful for preparing polymeric nanoparticles and evaluating particle size, stability, and surface characteristics.
- Polymeric Micelle Research: Supports investigation of amphiphilic polymer self-assembly and hydrophobic compound encapsulation.
- Targeted Drug Delivery: Enables attachment of amine-containing targeting ligands to polymeric delivery systems.
- Bioconjugation Research: Useful for EDC/NHS-mediated coupling of peptides, proteins, and other amine-functionalized biomolecules.
- Surface Functionalization: Supports modification of polymer nanoparticles with functional molecules and biological ligands.
- Biomaterials Research: Useful for developing biodegradable polymer systems for tissue engineering and biomedical material studies.
- Controlled Release Studies: Supports investigation of PLLA degradation, polymer composition, and drug release behavior.
- Polymer Characterization: Enables studies of molecular weight, hydrophilic-hydrophobic balance, self-assembly, and physicochemical properties.
Storage and Handling
- Storage: Store at −20°C in a dry, tightly sealed container unless otherwise specified. Protect from moisture and excessive heat.
- Handling: Handle under dry conditions to minimize moisture exposure. For carboxyl conjugation, use suitable EDC/NHS activation conditions and freshly prepared reaction solutions when appropriate.
PLLA-PEG-COOH, MW x 3K, n 3K combines biodegradable PLLA with hydrophilic PEG and reactive terminal carboxyl functionality, while its equal nominal block molecular weights support nanoparticle development, targeted drug delivery, bioconjugation, controlled release, and advanced biomaterials research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.