Fmoc-NH-PEG30-acid
This product is a long-chain PEG linker containing an Fmoc-protected amine, a PEG30 spacer, and a terminal carboxylic acid. The Fmoc group allows controlled deprotection under mild basic conditions, while the carboxyl couples efficiently with amines or activated esters. The extended PEG30 chain provides excellent solubility, flexibility, and long-distance spacing, making this reagent especially valuable for peptide synthesis, bioconjugation, and drug delivery.
Key Features and Benefits
-
Fmoc-Protected Amine: Stable during synthesis, removable with mild base.
-
Carboxylic Acid Group: Couples readily with amines to form stable amide bonds.
-
PEG30 Spacer: Provides long, flexible hydrophilic spacing for reduced steric hindrance.
-
Orthogonal Reactivity: Supports stepwise synthesis and multifunctional strategies.
-
High Purity: Produced to ≥95% purity for reproducible performance.
Applications
-
Peptide Synthesis: Incorporates long PEG spacers into peptides by SPPS.
-
Bioconjugation: Links proteins, probes, and carriers through amine/acid chemistry.
-
Drug Delivery: Functions as a PEGylated linker for targeted therapeutics.
-
Probe Development: Builds multifunctional probes with extended solubility and reach.
Storage and Handling
-
Storage: Store at –20 °C in a sealed, desiccated container.
-
Handling: Deprotect Fmoc under standard SPPS conditions; prepare fresh solutions before use.
This product combines an orthogonally protected amine with a reactive carboxyl on a long PEG30 chain, making it especially ideal for synthesis and bioconjugation requiring extended spacing.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
