Fmoc-NH-PEG5-acid
This product is a PEG linker containing an Fmoc-protected amine, a PEG5 spacer, and a terminal carboxylic acid. It specifically enables orthogonal amine deprotection and carboxyl coupling, offering solubility, flexibility, and controlled reactivity for bioconjugation and synthetic applications.
Key Features and Benefits
-
Fmoc-Protected Amine: Allows orthogonal protection with selective deprotection for conjugation.
-
Carboxylic Acid: Couples efficiently with primary amines to form stable amide bonds.
-
PEG5 Spacer: Provides solubility, flexibility, and moderate chain length.
-
Dual Reactivity: Combines protected amine chemistry with reactive carboxyl functionality.
-
High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
Applications
-
Bioconjugation: Links PEG chains to biomolecules with orthogonal control.
-
Probe Development: Builds multifunctional probes for imaging and diagnostics.
-
Drug Delivery: Provides PEG scaffolds with solubility and reactive groups.
-
Organic Synthesis: Serves as an intermediate for modular linker design.
Storage and Handling
-
Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
-
Handling: Use anhydrous solvents such as DMF or DMSO to maintain stability.
This product integrates Fmoc-protected amine chemistry with carboxyl functionality in a PEG5 scaffold, specifically offering solubility and orthogonal conjugation flexibility.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
