Fmoc-NH-PEG4-acid
This product is a heterobifunctional PEG linker containing an Fmoc-protected amine, a PEG4 spacer, and a terminal carboxylic acid. The Fmoc group allows controlled deprotection under mild basic conditions, while the carboxyl group couples readily with amines or activated esters. The PEG4 spacer improves solubility and flexibility, making this reagent especially suitable for peptide synthesis, bioconjugation, and drug development.
Key Features and Benefits
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Fmoc-Protected Amine: Stable during synthesis, removable with mild base.
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Carboxylic Acid Group: Couples efficiently with amines for stable amide formation.
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PEG4 Spacer: Enhances solubility, flexibility, and accessibility in conjugation.
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Stepwise Conjugation: Supports orthogonal protection strategies in synthesis.
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High Purity: Produced to ≥95% purity for reproducible results.
Applications
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Peptide Synthesis: Incorporates PEG spacers into peptides via SPPS.
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Bioconjugation: Couples to proteins, probes, and carriers through amine/acid chemistry.
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Drug Delivery: Serves as a linker for PEGylated therapeutics.
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Probe Development: Builds multifunctional PEG-based probes for diagnostics and imaging.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Deprotect Fmoc under standard conditions; prepare fresh solutions before use.
This product integrates an orthogonally protected amine with a reactive carboxyl handle on a PEG4 backbone, specifically offering a versatile tool for peptide chemistry and advanced bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
