Poly(L-Arginine)-PEG-N3, MW x 3.8K, n 2K is a functional block copolymer composed of poly(L-arginine) (PArg) and polyethylene glycol (PEG) with a terminal azide (N3) group. This grade combines approximately 3.8K PArg with 2K PEG, providing a PArg-rich architecture with guanidinium and azide functionality specifically for click chemistry, bioconjugation, drug delivery, polymer functionalization, and biomaterial research.
Key Features and Benefits
- Functional Block Copolymer: Combines cationic PArg with hydrophilic PEG and terminal azide functionality for polymer modification, conjugation, and biomaterial development.
- PArg MW 3.8K: Provides a poly(amino acid) segment with pendant guanidinium groups for ionic and molecular interactions.
- PEG MW 2K: Provides a hydrophilic segment specifically for aqueous compatibility, hydration, and interfacial stabilization.
- PArg-Rich Architecture: The approximately 1.9:1 PArg-to-PEG molecular weight ratio favors cationic PArg content while retaining a hydrophilic PEG component.
- Azide Functionality: Provides a terminal N3 group for click chemistry with compatible alkyne-functional molecules.
- Guanidinium-Rich Polymer: The PArg block provides positively charged guanidinium groups that support electrostatic interactions with negatively charged molecules and materials.
- Versatile Conjugation Platform: Combines terminal azide functionality with a cationic poly(L-arginine) block to support polymer modification, bioconjugation, and functional material development.
Applications
- CuAAC Click Chemistry: Supports copper-catalyzed azide-alkyne cycloaddition with terminal alkyne-functional molecules.
- Copper-Free Click Chemistry: Supports strain-promoted azide-alkyne cycloaddition (SPAAC) with compatible strained cyclooctyne groups.
- Bioconjugation: Enables attachment of peptides, proteins, ligands, and other biomolecules through azide-based click chemistry.
- Polymer Functionalization: Provides terminal azide functionality for attachment of compatible molecules and preparation of functional polymer conjugates.
- Drug Delivery: Supports development of functional polymer systems and drug-delivery carriers.
- Ionic Complex Formation: Provides guanidinium-containing PArg segments for electrostatic interactions with negatively charged molecules, polymers, and biomaterials.
- Biomaterial Research: Supports development of functional poly(amino acid)-PEG materials for conjugates, coatings, delivery systems, and related applications.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
This product combines cationic PArg, hydrophilic PEG, and terminal azide functionality in a PArg-rich block copolymer. It specifically supports click chemistry, bioconjugation, polymer functionalization, drug delivery, ionic complex formation, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.