Poly(L-Arginine)-mPEG, MW X 3.8K, n 5K is a functional block copolymer composed of poly(L-arginine) (PArg) and methoxy polyethylene glycol (mPEG). This grade combines approximately 3.8K PArg with 5K mPEG, providing an mPEG-rich architecture with guanidinium functionality and a substantial hydrophilic PEG segment specifically for polymer functionalization, bioconjugation, drug delivery, and biomaterial research.
Key Features and Benefits
- Functional Block Copolymer: Combines cationic PArg with hydrophilic mPEG for polymer modification, conjugation, drug delivery, and biomaterial development.
- PArg MW 3.8K: Provides a poly(amino acid) segment with pendant guanidinium groups for ionic and molecular interactions.
- mPEG MW 5K: Provides a substantial hydrophilic segment specifically for aqueous compatibility, hydration, and steric stabilization.
- mPEG-Rich Architecture: The approximately 3.8:5 PArg-to-mPEG molecular weight ratio favors hydrophilic mPEG character while retaining substantial cationic PArg content.
- Guanidinium-Rich Polymer: The PArg block provides positively charged guanidinium groups that support electrostatic interactions with negatively charged molecules and materials.
- Methoxy-Terminated PEG: Provides a nonreactive methoxy PEG terminus while the PArg block supplies the cationic functionality of the polymer.
- Functional Polymer Platform: Combines a cationic poly(L-arginine) segment with hydrophilic mPEG for development of functional polymer systems and biomaterials.
Applications
- Drug Delivery: Supports development of functional polymer systems and drug-delivery carriers.
- Ionic Complex Formation: Provides guanidinium-containing PArg segments for electrostatic interactions with negatively charged molecules, polymers, and biomaterials.
- Bioconjugation: Supports development of poly(L-arginine)-PEG conjugates and functional biomolecular systems.
- Polymer Functionalization: Provides a cationic poly(amino acid) block for incorporation into functional polymer systems.
- Nucleic Acid Delivery Research: Supports research involving electrostatic complexation with negatively charged nucleic acids and related delivery systems.
- Surface Modification: Supports development of cationic polymer coatings and modified biomaterial surfaces.
- Biomaterial Research: Supports development of functional poly(amino acid)-PEG materials for coatings, conjugates, delivery systems, and related applications.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
This product combines cationic PArg with hydrophilic mPEG in an mPEG-rich block copolymer. It specifically supports drug delivery, ionic complex formation, bioconjugation, polymer functionalization, nucleic acid delivery research, and biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
