Poly(DL‑lactide) (PDLLA, MW 300‑500K) is ultra‑high‑molecular‑weight amorphous biodegradable aliphatic polyester obtained by ring‑opening polymerization of racemic D,L‑lactide. Randomly distributed D‑ and L‑lactide repeat units disrupt chain regularity and completely suppress crystallinity, which is fundamentally different from semi‑crystalline PLLA homopolymer. This top‑tier ultra‑high‑MW PDLLA delivers extraordinary mechanical strength, supreme toughness and outstanding film‑forming performance, accompanied by extremely sluggish homogeneous hydrolytic degradation. Its fully amorphous microstructure enables uniform water diffusion throughout the polymer matrix, supporting continuous degradation and sustained drug release over multiple years. Degradation generates endogenous lactic acid that can be metabolized and eliminated in vivo with reliable biosafety. It is mainly utilized for high‑end absorbable structural polymer prototypes, heavy‑duty large‑scale implant biomaterials and multi‑year ultra‑long‑cycle tissue‑engineering research.
Key Features
- MW: 300000‑500000 Da, fully amorphous poly(DL‑lactide), no melting point; glass transition temperature Tg ≈56‑66 °C
- Amorphous microstructure guarantees homogeneous water infiltration and uniform hydrolytic degradation, avoiding heterogeneous degradation induced by crystalline domains
- Extraordinary mechanical strength and toughness; compatible with hot‑press molding, solvent casting, electrospinning and other high‑demand polymer processing workflows
- Excellent biocompatibility; degradation metabolite is endogenous lactic acid
- Soluble in DCM, CHCl₃, THF, DMF; insoluble in water, alcohols and aliphatic alkanes
- Extremely hygroscopic; ester bonds are highly vulnerable to moisture‑catalyzed hydrolysis; strict full‑process moisture‑proof operation is required
Applications
- Raw polymer for fabricating ultra‑high‑strength heavy‑duty large‑volume implant depots and bulky structural scaffolds for multi‑year ultra‑long‑term drug‑delivery research
- Feedstock for high‑toughness dense biodegradable films and high‑performance electrospun membranes applied in multi‑year tissue‑engineering research
- Prepolymer source for synthesizing ultra‑high‑molecular‑weight functional PDLLA derivatives
- Research‑grade raw material for developing high‑end heavy‑duty absorbable medical device prototypes
Handling & Storage
- Store at −20 °C under dry sealed condition; strictly moisture‑proof; prevent sharp temperature‑humidity fluctuations
- Fully equilibrate container to room temperature before opening package to avoid condensation‑water contamination
- Hermetically seal right after partial sampling; repeated freeze‑thaw cycles are strictly prohibited
- For research‑only use; not intended for direct clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.