PLLA-Thiol (PLLA-SH), MW 20K is a thiol-functionalized poly(L-lactide) with a molecular weight of approximately 20K. It combines a biodegradable PLLA backbone with terminal thiol functionality specifically for bioconjugation, surface modification, nanoparticle functionalization, polymer coupling, and biomaterial research.
Key Features and Benefits
- Thiol-Functionalized PLLA: Combines biodegradable poly(L-lactide) with a terminal thiol group for chemical modification and conjugation.
- MW 20K: Provides a moderate molecular weight that balances polymer processability, biodegradable matrix formation, and functionalization.
- Thiol Functionality: The terminal –SH group provides a reactive site specifically for thiol-selective coupling and surface attachment.
- Biodegradable Polyester: The PLLA backbone contains hydrolyzable ester linkages that specifically support gradual polymer degradation under appropriate conditions.
- Stereoregular PLLA Backbone: The L-lactide-derived polymer structure promotes crystallinity and provides useful structural and thermal properties.
- Conjugation Platform: The thiol terminus supports reactions with maleimide, vinyl sulfone, disulfide-forming reagents, and other thiol-reactive functionalities.
- Surface Affinity: Thiol functionality supports attachment to compatible metal surfaces, including gold, specifically for surface and nanoparticle modification research.
Applications
- Bioconjugation: Provides terminal thiol functionality for coupling PLLA with thiol-reactive molecules and biomolecular components.
- Thiol-Maleimide Coupling: Supports conjugation with maleimide-functionalized molecules, polymers, and surfaces.
- Surface Modification: Enables functionalization of compatible surfaces through thiol-mediated attachment or coupling reactions.
- Nanoparticle Functionalization: Supports preparation and surface modification of biodegradable polymer nanoparticles and hybrid nanomaterials.
- Gold Surface Functionalization: The thiol group supports interaction with gold surfaces and gold nanoparticles for materials research.
- Polymer Conjugation: Provides a reactive terminal group for preparing block, graft, and other functional polymer architectures.
- Drug Delivery: Supports development of functional biodegradable polymer systems for drug-delivery and controlled-release research.
- Biomaterial Research: Supports development of functional biodegradable polymers, coatings, particles, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and prolonged exposure to air.
- Handling: Minimize exposure to oxygen and moisture to reduce thiol oxidation and disulfide formation. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
This product provides a biodegradable PLLA platform with terminal thiol functionality for selective conjugation and surface modification. It specifically supports bioconjugation, nanoparticle functionalization, polymer coupling, drug delivery, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.