PLLA-Thiol (PLLA-SH), MW 10K is a thiol-functionalized poly(L-lactide) with a molecular weight of approximately 10K. It combines a biodegradable PLLA backbone with terminal thiol functionality specifically for bioconjugation, surface modification, nanoparticle functionalization, polymer coupling, and biomaterial research.
Key Features and Benefits
- Thiol-Functionalized PLLA: Combines biodegradable poly(L-lactide) with a terminal thiol group for chemical modification and conjugation.
- MW 10K: Provides a lower molecular weight with good processability specifically for polymer functionalization, formulation, and conjugation research.
- Thiol Functionality: The terminal –SH group provides a reactive site for thiol-selective coupling and surface attachment.
- Biodegradable Polyester: The PLLA backbone contains hydrolyzable ester linkages that specifically support gradual polymer degradation under appropriate conditions.
- Stereoregular PLLA Backbone: The L-lactide-derived polymer structure promotes crystallinity and provides useful structural and thermal properties.
- Conjugation Platform: The thiol terminus specifically supports reactions with maleimide, vinyl sulfone, disulfide-forming reagents, and other thiol-reactive functionalities.
- Surface Affinity: Thiol functionality supports attachment to compatible metal surfaces, including gold, for surface and nanoparticle modification research.
Applications
- Bioconjugation: Provides terminal thiol functionality for coupling PLLA with thiol-reactive molecules and biomolecular components.
- Thiol-Maleimide Coupling: Supports conjugation with maleimide-functionalized molecules, polymers, and surfaces.
- Surface Modification: Enables functionalization of compatible surfaces through thiol-mediated attachment or coupling reactions.
- Nanoparticle Functionalization: Supports preparation and surface modification of biodegradable polymer nanoparticles and hybrid nanomaterials.
- Gold Surface Functionalization: The thiol group supports interaction with gold surfaces and gold nanoparticles for materials research.
- Polymer Conjugation: Provides a reactive terminal group for preparing block, graft, and other functional polymer architectures.
- Drug Delivery: Supports development of functional biodegradable polymer systems for drug-delivery and controlled-release research.
- Biomaterial Research: Supports development of functional biodegradable polymers, coatings, particles, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and prolonged exposure to air.
- Handling: Minimize exposure to oxygen and moisture to reduce thiol oxidation and disulfide formation. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
This product provides a biodegradable PLLA platform with terminal thiol functionality and good processability for selective conjugation and surface modification. It specifically supports bioconjugation, nanoparticle functionalization, polymer coupling, drug delivery, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.