PLLA-Thiol (PLLA-SH), MW 5K

PLLA-Thiol (PLLA-SH), MW 5K is a thiol-functionalized poly(L-lactide) with a molecular weight of approximately 5K. It combines a low-molecular-weight biodegradable PLLA backbone with terminal thiol functionality specifically for bioconjugation, surface modification, nanoparticle functionalization, polymer coupling, and biomaterial research.

Key Features and Benefits

• Thiol-Functionalized PLLA: Combines biodegradable poly(L-lactide) with a terminal thiol group for chemical modification and conjugation.
• MW 5K: Provides a low molecular weight with good processability for polymer functionalization, formulation, and conjugation research.
• Thiol Functionality: The terminal –SH group provides a reactive site for thiol-selective coupling and surface attachment.
• Biodegradable Polyester: The PLLA backbone contains hydrolyzable ester linkages that specifically support gradual polymer degradation under appropriate conditions.
• Stereoregular PLLA Backbone: The L-lactide-derived polymer structure promotes crystallinity and provides especially useful structural and thermal properties.
• Good Processability: The lower molecular weight facilitates polymer dissolution, formulation, and chemical modification compared with higher-molecular-weight PLLA grades.
• Conjugation Platform: The thiol terminus supports reactions with maleimide, vinyl sulfone, disulfide-forming reagents, and other thiol-reactive functionalities.
• Surface Affinity: Thiol functionality specifically supports attachment to compatible metal surfaces, including gold, for surface and nanoparticle modification research.

Applications

• Bioconjugation: Provides terminal thiol functionality for coupling PLLA with thiol-reactive molecules and biomolecular components.
• Thiol-Maleimide Coupling: Supports conjugation with maleimide-functionalized molecules, polymers, and surfaces.
• Surface Modification: Enables functionalization of compatible surfaces through thiol-mediated attachment or coupling reactions.
• Nanoparticle Functionalization: Supports preparation and surface modification of biodegradable polymer nanoparticles and hybrid nanomaterials.
• Gold Surface Functionalization: The thiol group supports interaction with gold surfaces and gold nanoparticles for materials research.
• Polymer Conjugation: Provides a reactive terminal group for preparing block, graft, and other functional polymer architectures.
• Drug Delivery: Supports development of functional biodegradable polymer systems for drug-delivery and controlled-release research.
• Biomaterial Research: Supports development of functional biodegradable polymers, coatings, particles, composites, and related biomaterials.

Storage and Handling

• Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and prolonged exposure to air.
• Handling: Minimize exposure to oxygen and moisture to reduce thiol oxidation and disulfide formation. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.

PLLA-Thiol (PLLA-SH), MW 5K provides a low-molecular-weight biodegradable PLLA platform with terminal thiol functionality and good processability. It specifically supports bioconjugation, surface modification, nanoparticle functionalization, polymer coupling, and biomaterial research.