α‑Hydroxyl‑ω‑Azide‑poly(L‑lactide) (PLLA‑N₃, MW 10K) is linear, mono‑azide‑terminated semi‑crystalline biodegradable aliphatic polyester. The polymer backbone is constructed from stereoregular L‑lactide repeating units and shows obvious semi‑crystallinity, which differs from fully‑amorphous PDLLA. Compared with MW 5K PLLA‑N₃, this 10 kDa grade exhibits higher hydrophobicity and slower homogeneous hydrolytic degradation. One polymer terminus carries click‑reactive azide (‑N₃) group, the opposite terminus retains inert hydroxyl (‑OH). Terminal azide group undergoes copper‑catalyzed azide‑alkyne cycloaddition (CuAAC) and strain‑promoted azide‑alkyne cycloaddition (SPAAC) click reactions, enabling efficient covalent bioconjugation with alkyne‑ or DBCO‑modified peptides, targeting ligands and biomolecules under mild bio‑orthogonal conditions. It acts as monofunctional click‑chemistry building block for slow‑degrading nanoparticle / microsphere fabrication, surface azido‑functionalization and long‑term biodegradable biomedical delivery research.
Key Features
- MW: 10000 Da, linear α‑hydroxyl‑ω‑azide‑terminated poly(L‑lactide)
- Semi‑crystalline stereoregular L‑lactide structure, distinct from amorphous PDLLA
- Higher hydrophobicity, slower and uniform hydrolytic degradation versus 5K PLLA‑N₃
- Excellent biocompatibility; degrades into non‑toxic L‑lactic acid in vitro and in vivo
- Single terminal azide (‑N₃) click‑reactive group; compatible with CuAAC and SPAAC bio‑orthogonal reactions; opposite polymer end is inert hydroxyl ‑OH
- Narrow molecular‑weight distribution, stable batch‑to‑batch reproducibility; high azide end‑group functionality
- Soluble in DCM, CHCl₃, THF, DMF, hot acetone; insoluble in water
- Azide‑terminated polymer; avoid strong mechanical impact, high‑temperature heating and heavy‑metal contaminants; store away from shock sources
Applications
- Monofunctional click‑chemistry building block for bioconjugation with alkyne / DBCO‑activated peptides, targeting ligands and biomacromolecules
- Fabrication of azide‑functional slow‑degrading PLLA nanoparticles and microspheres for long‑term drug‑delivery research
- Azido surface modification of semi‑crystalline polyester biomaterials for subsequent bio‑orthogonal grafting
- Precursor for synthesizing PLLA‑derived click‑based block and graft copolymers
- Research‑grade raw material for bio‑orthogonally‑modified degradable biomedical polymer study
Handling & Storage
- Store at −20 °C under dry inert nitrogen or argon atmosphere; strictly moisture‑proof, avoid shock and excessive heating
- Keep hermetically sealed; humidity accelerates polyester backbone hydrolysis; avoid repeated freeze‑thaw cycles
- For research‑only use; not intended for clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.