α‑Hydroxyl‑ω‑Amine‑poly(L‑lactide) (PLLA‑NH₂, MW 16K) is linear, mono‑amine‑terminated semi‑crystalline biodegradable aliphatic polyester. The polymer backbone consists of stereoregular L‑lactide repeating units and exhibits prominent crystallinity, distinctly different from fully‑amorphous PDLLA. Compared with MW 10K PLLA‑NH₂, this 16 kDa grade possesses further elevated hydrophobicity and very slow homogeneous hydrolytic degradation rate. One polymer terminus bears nucleophilic primary amine (‑NH₂) group, the opposite terminus retains inert hydroxyl (‑OH). Terminal primary amine can form stable amide bonds with carboxyl‑containing molecules under EDC/NHS activation, and readily reacts with NHS‑ester, aldehyde, isocyanate and epoxy moieties to achieve covalent bioconjugation with peptides, proteins and targeting ligands. It serves as monofunctional macromolecular initiator and modification building block for very‑slow‑degrading microsphere / scaffold fabrication, surface functionalization and long‑term sustained‑release biomedical research.
Key Features
- MW: 16000 Da, linear α‑hydroxyl‑ω‑amine‑terminated poly(L‑lactide)
- Semi‑crystalline stereoregular L‑lactide structure, distinct from amorphous PDLLA
- High hydrophobicity, very slow and uniform hydrolytic degradation versus 10K PLLA‑NH₂
- Excellent biocompatibility; degrades into non‑toxic L‑lactic acid in vitro and in vivo
- Single terminal primary amine (‑NH₂) group with high nucleophilic reactivity for amide coupling and multiple organic reactions; opposite polymer end is inert hydroxyl ‑OH
- Narrow molecular‑weight distribution, stable batch‑to‑batch reproducibility; high amine end‑group functionality
- Soluble in DCM, CHCl₃, THF, DMF, hot acetone; insoluble in water
- Amine group is moisture‑sensitive; avoid prolonged exposure to humid air and acidic contaminants
Applications
- Monofunctional building block for amide‑based bioconjugation with carboxyl‑modified peptides, proteins and targeting moieties
- Macro‑initiator for NCA ring‑opening polymerization to synthesize high‑molecular‑weight PLLA‑based block copolymers
- Preparation of amine‑functional very‑slow‑degrading PLLA microspheres and porous scaffolds for long‑term sustained drug‑delivery research
- Amino surface modification of polyester implant‑related biomaterials to improve cell adhesion and biological affinity
- Research‑grade raw material for constructing high‑molecular‑weight degradable biomedical polymer conjugates
Handling & Storage
- Store at −20 °C under dry inert nitrogen or argon atmosphere; strictly moisture‑proof
- Keep hermetically sealed; humidity may deactivate amine end‑groups and accelerate polyester hydrolysis; avoid repeated freeze‑thaw cycles
- For research‑only use; not intended for clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.