α‑Hydroxyl‑ω‑Amine‑poly(L‑lactide) (PLLA‑NH₂, MW 10K) is linear, mono‑amine‑terminated semi‑crystalline biodegradable aliphatic polyester. Its polymer backbone is built from stereoregular L‑lactide repeating units, possessing obvious crystallinity which differentiates it from fully‑amorphous PDLLA. Compared with MW 5K PLLA‑NH₂, this 10 kDa grade shows higher hydrophobicity and slower homogeneous hydrolytic degradation. One polymer terminus bears nucleophilic primary amine (‑NH₂) group, the opposite terminus retains inert hydroxyl (‑OH). Terminal primary amine can form stable amide bonds with carboxyl‑containing molecules under EDC/NHS activation, and reacts with NHS‑ester, aldehyde, isocyanate and epoxy groups for covalent bioconjugation with peptides, proteins and targeting ligands. It works as monofunctional macromolecular initiator and modification building block for slow‑degrading nanoparticle/microsphere fabrication, surface functionalization and long‑term biomedical delivery research.
Key Features
- MW: 10000 Da, linear α‑hydroxyl‑ω‑amine‑terminated poly(L‑lactide)
- Semi‑crystalline stereoregular L‑lactide structure, distinct from amorphous PDLLA
- Higher hydrophobicity, slower and uniform hydrolytic degradation versus 5K PLLA‑NH₂
- Excellent biocompatibility; degrades into non‑toxic L‑lactic acid in vitro and in vivo
- Single terminal primary amine (‑NH₂) group with high nucleophilic reactivity for amide coupling and multiple organic reactions; opposite polymer end is inert hydroxyl ‑OH
- Narrow molecular‑weight distribution, stable batch‑to‑batch reproducibility; high amine end‑group functionality
- Soluble in DCM, CHCl₃, THF, DMF, hot acetone; insoluble in water
- Amine group is moisture‑sensitive; avoid prolonged exposure to humid air and acidic contaminants
Applications
- Monofunctional building block for amide‑based bioconjugation with carboxyl‑modified peptides, proteins and targeting moieties
- Macro‑initiator for NCA ring‑opening polymerization to synthesize PLLA‑based block copolymers
- Preparation of amine‑functional slow‑degrading PLLA nanoparticles, microspheres for long‑term drug‑delivery research
- Amino surface modification of polyester biomaterials to enhance cell adhesion and biological affinity
- Research‑grade raw material for constructing high‑molecular‑weight degradable biomedical polymer conjugates
Handling & Storage
- Store at −20 °C under dry inert nitrogen or argon atmosphere; strictly moisture‑proof
- Keep hermetically sealed; humidity may deactivate amine end‑groups and accelerate polyester hydrolysis; avoid repeated freeze‑thaw cycles
- For research‑only use; not intended for clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.