α‑Hydroxyl‑ω‑Amine‑poly(L‑lactide) (PLLA‑NH₂, MW 5K) is linear, mono‑amine‑terminated semi‑crystalline biodegradable aliphatic polyester. Its polymer backbone is constructed from stereoregular L‑lactide repeating units, showing inherent crystallinity different from fully‑amorphous PDLLA. Compared with MW 2K PLLA‑NH₂, this 5 kDa grade exhibits moderate hydrophobicity and intermediate hydrolytic degradation rate. One polymer terminus carries nucleophilic primary amine (‑NH₂) group, the opposite terminus retains inert hydroxyl (‑OH). Terminal primary amine can form stable amide bonds with carboxyl‑containing molecules under EDC/NHS activation, and readily reacts with NHS‑ester, aldehyde, isocyanate and epoxy moieties for covalent bioconjugation with peptides, proteins and targeting ligands. It serves as monofunctional macromolecular initiator and modification building block for medium‑degradation‑rate nanoparticle fabrication, surface functionalization and biomedical delivery research.
Key Features
- MW: 5000 Da, linear α‑hydroxyl‑ω‑amine‑terminated poly(L‑lactide)
- Semi‑crystalline stereoregular L‑lactide structure, distinct from amorphous PDLLA
- Moderate hydrophobicity, intermediate hydrolytic degradation versus 2K PLLA‑NH₂
- Excellent biocompatibility; degrades into non‑toxic L‑lactic acid in vitro and in vivoFrontiers
- Single terminal primary amine (‑NH₂) group with high nucleophilic reactivity for amide coupling and multiple organic reactions; opposite polymer end is inert hydroxyl ‑OH
- Narrow molecular‑weight distribution, stable batch‑to‑batch reproducibility; high amine end‑group functionality
- Soluble in DCM, CHCl₃, THF, DMF, acetone; insoluble in water
- Amine group is moisture‑sensitive; avoid prolonged exposure to humid air and acidic contaminants
Applications
- Monofunctional building block for amide‑based bioconjugation with carboxyl‑modified peptides, proteins and targeting moieties
- Macro‑initiator for NCA ring‑opening polymerization to synthesize PLLA‑based block copolymers
- Preparation of amine‑functional PLLA nanoparticles and microspheres with medium degradation speed for drug‑delivery research
- Amino surface modification of polyester biomaterials to enhance cell adhesion and affinity
- Research‑grade raw material for constructing degradable biomedical polymer conjugates
Handling & Storage
- Store at −20 °C under dry inert nitrogen or argon atmosphere; strictly moisture‑proof
- Keep hermetically sealed; humidity may deactivate amine end‑groups and accelerate polyester hydrolysis; avoid repeated freeze‑thaw cycles
- For research‑only use; not intended for clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.