PLLA-Amine (PLLA-NH2), MW 5K is an amine-functionalized poly(L-lactide) with a molecular weight of approximately 5K. It combines a low-molecular-weight biodegradable PLLA backbone with terminal primary amine functionality specifically for bioconjugation, polymer functionalization, surface modification, nanoparticle functionalization, and biomaterial research.
Key Features and Benefits
- Amine-Functionalized PLLA: Combines biodegradable poly(L-lactide) with a terminal primary amine group for chemical modification and conjugation.
- MW 5K: Provides a low molecular weight with good processability specifically for polymer functionalization, formulation, and conjugation research.
- Primary Amine Functionality: The terminal –NH2 group provides a reactive site for coupling with carboxyl, NHS ester, isocyanate, and other amine-reactive functionalities.
- Biodegradable Polyester: The PLLA backbone contains hydrolyzable ester linkages that specifically support gradual polymer degradation under appropriate conditions.
- Stereoregular PLLA Backbone: The L-lactide-derived polymer structure promotes crystallinity and provides useful polymer properties.
- Good Processability: The lower molecular weight facilitates polymer dissolution, formulation, and chemical modification compared with higher-molecular-weight PLLA grades.
- Versatile Conjugation Platform: Terminal amine functionality supports attachment of compatible polymers, biomolecules, ligands, probes, and other functional components.
Applications
- Bioconjugation: Provides terminal amine functionality for coupling PLLA with compatible biomolecules, ligands, and functional molecules.
- Amide Coupling: Supports conjugation with carboxyl-containing compounds using appropriate coupling chemistry.
- NHS Ester Conjugation: Reacts with NHS ester-functionalized molecules, polymers, and surfaces to form stable amide linkages.
- Polymer Functionalization: Enables preparation of functional PLLA derivatives, block polymers, and other polymer architectures.
- Nanoparticle Functionalization: Supports preparation and surface modification of biodegradable polymer nanoparticles and related delivery systems.
- Surface Modification: Provides a reactive amine group for attachment to compatible functionalized surfaces and materials.
- Drug Delivery: Supports development of functional biodegradable polymer systems for drug-delivery and controlled-release research.
- Biomaterial Research: Supports development of functional biodegradable polymers, particles, coatings, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and excessive heat.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
PLLA-Amine (PLLA-NH2), MW 5K provides a low-molecular-weight biodegradable PLLA platform with terminal primary amine functionality and good processability and specifically supports bioconjugation, polymer functionalization, nanoparticle modification, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.