PDLLA-Maleimide (PDLLA-Mal), MW 5K is a maleimide-functionalized poly(DL-lactide) with a molecular weight of approximately 5K. It combines a low-molecular-weight, biodegradable amorphous PDLLA backbone with terminal maleimide functionality specifically for thiol-selective conjugation, bioconjugation, polymer functionalization, nanoparticle modification, and biomaterial research.
Key Features and Benefits
- Maleimide-Functionalized PDLLA: Combines biodegradable poly(DL-lactide) with a terminal maleimide group for chemical modification and conjugation.
- MW 5K: Provides a low molecular weight with good processability specifically for polymer functionalization, formulation, and conjugation research.
- Maleimide Functionality: The terminal maleimide group provides a reactive site specifically for selective coupling with thiol-containing molecules under appropriate reaction conditions.
- Thiol-Reactive Platform: Supports thiol-maleimide coupling to form stable covalent linkages with compatible thiol-functionalized components.
- Biodegradable Polyester: The PDLLA backbone contains hydrolyzable ester linkages that support gradual polymer degradation under appropriate conditions.
- Amorphous PDLLA Backbone: The random distribution of D- and L-lactide units limits crystallization and provides an amorphous polymer structure.
- Good Processability: The lower molecular weight facilitates polymer dissolution, formulation, and chemical modification compared with higher-molecular-weight PDLLA grades.
- Versatile Conjugation Platform: Maleimide functionality supports attachment of thiol-containing polymers, peptides, proteins, ligands, and other functional molecules.
Applications
- Thiol-Maleimide Coupling: Supports selective conjugation with thiol-functionalized molecules, polymers, and surfaces.
- Bioconjugation: Provides terminal maleimide functionality for coupling PDLLA with thiol-containing peptides, proteins, ligands, and other biomolecules.
- Polymer Functionalization: Enables preparation of functional PDLLA derivatives, block polymers, and other polymer architectures.
- Nanoparticle Functionalization: Supports preparation and surface modification of biodegradable polymer nanoparticles and related delivery systems.
- Surface Modification: Enables attachment of PDLLA to compatible thiol-functionalized surfaces and materials.
- Drug Delivery: Supports development of functional biodegradable polymer systems for drug-delivery and controlled-release research.
- Ligand Conjugation: Provides a reactive maleimide group for attaching compatible thiol-containing targeting or functional ligands.
- Biomaterial Research: Supports development of functional biodegradable polymers, particles, coatings, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and excessive heat.
- Handling: Protect from moisture because maleimide groups can undergo hydrolysis under inappropriate conditions. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
PDLLA-Maleimide (PDLLA-Mal), MW 5K provides a low-molecular-weight, amorphous biodegradable PDLLA platform with terminal maleimide functionality and good processability and specifically supports thiol-selective conjugation, bioconjugation, nanoparticle functionalization, polymer modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.