PDLLA-Biotin (PDLLA-Bio), MW 20K is a biotin-functionalized poly(DL-lactide) with a molecular weight of approximately 20K. It combines a biodegradable amorphous PDLLA backbone with terminal biotin functionality specifically for avidin-biotin binding, bioconjugation, surface modification, nanoparticle functionalization, and biomaterial research.
Key Features and Benefits
- Biotin-Functionalized PDLLA: Combines biodegradable poly(DL-lactide) with a terminal biotin group for affinity-based binding and functionalization.
- MW 20K: Provides a moderate molecular weight that balances polymer processability, biodegradable matrix formation, and functionalization.
- Biotin Functionality: The terminal biotin group provides a high-affinity recognition site specifically for avidin, streptavidin, and related biotin-binding proteins.
- Biodegradable Polyester: The PDLLA backbone contains hydrolyzable ester linkages that specifically support gradual polymer degradation under appropriate conditions.
- Amorphous PDLLA Backbone: The random distribution of D- and L-lactide units specifically limits crystallization and provides an amorphous polymer structure.
- Affinity-Based Conjugation: Biotin functionality supports noncovalent assembly with streptavidin- or avidin-containing molecules, surfaces, and materials.
- Versatile Functionalization Platform: Enables incorporation of biotin recognition into biodegradable polymer particles, coatings, matrices, and other polymer systems.
Applications
- Avidin-Biotin Binding: Supports high-affinity interactions with avidin, streptavidin, and related biotin-binding proteins.
- Bioconjugation: Enables affinity-based attachment of PDLLA to compatible biotin-binding biomolecules and functional components.
- Nanoparticle Functionalization: Supports preparation and surface functionalization of biodegradable polymer nanoparticles for affinity-based research.
- Surface Modification: Enables incorporation of biotin functionality into PDLLA-containing surfaces, coatings, and materials.
- Affinity Capture: Supports development of polymer systems for affinity binding, immobilization, and capture studies.
- Drug Delivery: Supports development of functional biodegradable polymer systems for drug-delivery and controlled-release research.
- Polymer Functionalization: Provides a biotin-functionalized PDLLA platform for preparing multicomponent and affinity-based polymer systems.
- Biomaterial Research: Supports development of functional biodegradable polymers, particles, coatings, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and excessive heat.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
This product provides an amorphous biodegradable PDLLA platform with terminal biotin functionality for affinity-based binding and functionalization and specifically supports avidin-biotin interactions, bioconjugation, nanoparticle functionalization, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.