α‑Hydroxyl‑ω‑amino‑poly(D,L‑lactide) (PDLLA‑NH₂, MW 2K) is linear, mono‑amino‑terminated fully amorphous biodegradable aliphatic polyester. D‑lactide and L‑lactide repeat units are randomly distributed along polymer backbone, disrupting stereoregularity and eliminating crystalline domains. This low‑molecular‑weight 2 kDa variant exhibits relatively fast and homogeneous hydrolytic degradation compared with higher‑MW PDLLA‑NH₂ analogues. One chain terminus carries reactive primary amine (‑NH₂), the opposite end retains hydroxyl (‑OH). Terminal primary amine readily conjugates with NHS‑ester, carboxyl, aldehyde and epoxy functional groups to form stable covalent linkages, while the hydroxyl end remains chemically inert under amine‑coupling conditions. It serves as a monofunctional macro‑monomer for bioconjugation, nanoparticle surface amination, and post‑polymerization modification in biomedical research.
Key Features
- MW: 2000 Da, linear α‑hydroxyl‑ω‑amino‑terminated poly(D,L‑lactide)
- Fully amorphous non‑crystalline structure, random D/L‑lactide sequence, no melting point
- Relatively fast, uniform hydrolytic degradation versus higher‑MW PDLLA‑NH₂
- Good biocompatibility; degradation produces non‑toxic lactic‑acid metabolites
- Single reactive primary‑NH₂ terminus; reacts with NHS‑ester, COOH, aldehyde, epoxy groups; opposite end is inert hydroxyl ‑OH
- Narrow molecular‑weight distribution, consistent batch‑to‑batch performance
- Soluble in DCM, CHCl₃, THF, DMF, acetone; insoluble in water
- Amine end‑group is moisture‑sensitive; avoid prolonged exposure to ambient atmosphere
Applications
- Monofunctional building block for bioconjugation with NHS‑ester‑activated peptides, targeting ligands and fluorescent dyes
- Amine‑functional surface modification of PDLLA‑based nanoparticles and microspheres
- Precursor for post‑modification of biodegradable polyester materials
- Research‑grade raw material for preparing charge‑switchable drug‑delivery carriers
Handling & Storage
- Store at −20 °C under dry inert nitrogen or argon atmosphere; strictly moisture‑proof
- Keep hermetically sealed; moisture will deactivate amine end‑groups and trigger ester hydrolysis; avoid repeated freeze‑thaw cycles
- For research‑only use; not intended for clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.